BDBM439415 (S)-4-(4-(tert-butoxy)-2-(4-(5-chloro-2-propionylphenyl)-5-methoxy-2-oxopyridin-1(2H)-yl)butanamido)benzoic acid::US10633375, Compound No. 108::US10633375, Compound No. 177::US11084808, Compound 177

SMILES CCC(=O)c1ccc(Cl)cc1-c1cc(=O)n(cc1OC)[C@@H](CCOC(C)(C)C)C(=O)Nc1ccc(cc1)C(O)=O

InChI Key InChIKey=URWDPFQYGVUECB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 439415   

TargetCoagulation factor XI(Human)
Jinagsu Hengrui Medicine

US Patent
LigandPNGBDBM439415((S)-4-(4-(tert-butoxy)-2-(4-(5-chloro-2-propionylp...)
Affinity DataIC50: 12nMAssay Description:Test Example 1: Biological Activity of the Compounds of the Present Invention onThe Inhibition of Factor XIa Detected by Absorption Photometry1. Expe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2021
Entry Details
Go to US Patent

TargetCoagulation factor XI(Human)
Jinagsu Hengrui Medicine

US Patent
LigandPNGBDBM439415((S)-4-(4-(tert-butoxy)-2-(4-(5-chloro-2-propionylp...)
Affinity DataIC50: 27nMAssay Description:Test Example 1: Biological Activity of the Compounds of the Present Invention onThe Inhibition of Factor XIa Detected by Absorption Photometry1. Expe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2021
Entry Details
Go to US Patent

TargetCoagulation factor XI(Human)
Jinagsu Hengrui Medicine

US Patent
LigandPNGBDBM439415((S)-4-(4-(tert-butoxy)-2-(4-(5-chloro-2-propionylp...)
Affinity DataIC50: 27nMAssay Description:1. Experimental MaterialsEnzyme: Coagulation Factor XIa protease (Abcam, Art. No ab62411)Substrate: Coagulation Factor XIa specific substrate (HYPHEN...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2022
Entry Details
Go to US Patent

TargetCoagulation factor XI(Human)
Jinagsu Hengrui Medicine

US Patent
LigandPNGBDBM439415((S)-4-(4-(tert-butoxy)-2-(4-(5-chloro-2-propionylp...)
Affinity DataIC50: 12nMAssay Description:1. Experimental MaterialsEnzyme: Coagulation Factor XIa protease (Abcam, Art. No ab62411)Substrate: Coagulation Factor XIa specific substrate (HYPHEN...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2022
Entry Details
Go to US Patent