BDBM438823 (S)-4-(2-(2-((3'-(5-(2- hydroxypropyl)-1-methyl- 4,5,6,7-tetrahydro-1H- imidazo[4,5-c]pyridine-2- carboxamido)-2,2'- dimethyl-[1,1'-biphenyl]-3- yl)carbamoyl)-1-methyl- 1,4,6,7-tetrahydro-5H- imidazo[4,5-c]pyridin-5- yl)ethyl)bicyclo[2.2.1] heptane-1-carboxylic acid::US10618916, Example 58::US10906920, Example 58::US11414433, Example 58

SMILES C[C@H](O)CN1CCc2c(C1)nc(C(=O)Nc1cccc(c1C)-c1cccc(NC(=O)c3nc4CN(CCC56CCC(CC5)(C6)C(O)=O)CCc4n3C)c1C)n2C

InChI Key InChIKey=PGSGVXNCCRAVBB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 438823   

LigandPNGBDBM438823((S)-4-(2-(2-((3'-(5-(2- hydroxypropyl)-1-methyl- 4...)
Affinity DataIC50: 5nMAssay Description:The assays were conducted in a standard black 384-well polystyrene plate with a final volume of 20 μL. Inhibitors were first serially diluted in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
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LigandPNGBDBM438823((S)-4-(2-(2-((3'-(5-(2- hydroxypropyl)-1-methyl- 4...)
Affinity DataIC50: 5nMAssay Description:The assays were conducted in a standard black 384-well polystyrene plate with a final volume of 20 μL. Inhibitors were first serially diluted in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
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TargetProgrammed cell death 1 ligand/protein 1(Human)
Incyte

US Patent
LigandPNGBDBM438823((S)-4-(2-(2-((3'-(5-(2- hydroxypropyl)-1-methyl- 4...)
Affinity DataIC50: 5nMAssay Description:The assays were conducted in a standard black 384-well polystyrene plate with a final volume of 20 μL. Inhibitors were first serially diluted in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2022
Entry Details
Go to US Patent