BDBM436437 (R)-2-(ethylamino)-9- methyl-6-(3-((3- (methylamino)-1- (thiophen-2- yl)propoxy)methyl) phenyl)-6,7,8,9-tetrahydro- 5H-pyrimido[4,5- e][1,4]diazepin-5-one::US10590140, Example 212

SMILES CCNc1ncc2c(n1)N(C)CCN(c1cccc(CO[C@H](CCNC)c3cccs3)c1)C2=O

InChI Key InChIKey=XJHDXJNNMHSVDG-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 436437   

TargetVoltage-dependent calcium channel subunit alpha-2/delta-1 [25-1103](Human)
Esteve Pharmaceuticals

US Patent
LigandPNGBDBM436437(US10590140, Example 212 | (R)-2-(ethylamino)-9- me...)
Affinity DataKi:  300nMAssay Description:α2δ-1: Binding Assay to Human α2δ-1 Subunit of Cav2.2 Calcium Channel.Human α2δ-1 enriched membranes (2.5 μg) were...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetVoltage-dependent calcium channel subunit alpha-2/delta-1 [25-1103](Human)
Esteve Pharmaceuticals

US Patent
LigandPNGBDBM436437(US10590140, Example 212 | (R)-2-(ethylamino)-9- me...)
Affinity DataKi:  300nMAssay Description:α2δ-1: Binding Assay to Human α2δ-1 Subunit of Cav2.2 Calcium Channel.Human α2δ-1 enriched membranes (2.5 μg) were...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetSodium-dependent noradrenaline transporter(Human)
Esteve Pharmaceuticals

US Patent
LigandPNGBDBM436437(US10590140, Example 212 | (R)-2-(ethylamino)-9- me...)
Affinity DataKi:  300nMAssay Description:NET: Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent