BDBM435719 US10570155, Compound 2III::US11332479, Compound 2III

SMILES COc1ccc(cc1)S(=O)(=O)NCCNc1nccc(n1)-c1c(nc2sccn12)-c1ccccc1

InChI Key InChIKey=DUAGJVFSWKNHNE-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 435719   

TargetSerine/threonine-protein kinase B-raf(Human)
Korea Institute of Science and Technology

US Patent
LigandPNGBDBM435719(US10570155, Compound 2III | US11332479, Compound 2...)
Affinity DataIC50: 459nMAssay Description:Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Korea Institute of Science and Technology

US Patent
LigandPNGBDBM435719(US10570155, Compound 2III | US11332479, Compound 2...)
Affinity DataIC50: 77nMAssay Description:Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Korea Institute of Science and Technology

US Patent
LigandPNGBDBM435719(US10570155, Compound 2III | US11332479, Compound 2...)
Affinity DataIC50: 459nMAssay Description:Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Korea Institute of Science and Technology

US Patent
LigandPNGBDBM435719(US10570155, Compound 2III | US11332479, Compound 2...)
Affinity DataIC50: 77nMAssay Description:Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Korea Institute of Science and Technology

US Patent
LigandPNGBDBM435719(US10570155, Compound 2III | US11332479, Compound 2...)
Affinity DataIC50: 459nMAssay Description:Inhibition of human wild type BRAF using myelin basic protein as substrate in presence of [gamma-33P]ATP incubated for 40 mins by scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Korea Institute of Science and Technology

US Patent
LigandPNGBDBM435719(US10570155, Compound 2III | US11332479, Compound 2...)
Affinity DataIC50: 78nMAssay Description:Inhibition of human BRAF V600E mutant using myelin basic protein as substrate in presence of [gamma-33P]ATP incubated for 40 mins by scintillation co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
National Research Centre (Nrc)

Curated by ChEMBL
LigandPNGBDBM435719(US10570155, Compound 2III | US11332479, Compound 2...)
Affinity DataIC50: 172nMAssay Description:Inhibition of human wild type CRAF using myelin basic protein as substrate in presence of [gamma-33P]ATP incubated for 40 mins by scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed