BDBM435718 US10570155, Compound 2II::US11332479, Compound 2II

SMILES CCN1CCN(CCNc2nccc(n2)-c2c(nc3occn23)-c2cccc(O)c2)S1(=O)=O

InChI Key InChIKey=NRUJDQAGOKDQBH-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 435718   

TargetSerine/threonine-protein kinase B-raf(Human)
Korea Institute of Science and Technology

US Patent
LigandPNGBDBM435718(US10570155, Compound 2II | US11332479, Compound 2I...)
Affinity DataIC50: 0.0400nMAssay Description:Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Korea Institute of Science and Technology

US Patent
LigandPNGBDBM435718(US10570155, Compound 2II | US11332479, Compound 2I...)
Affinity DataIC50: 0.670nMAssay Description:Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
Go to US Patent

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Korea Institute of Science and Technology

US Patent
LigandPNGBDBM435718(US10570155, Compound 2II | US11332479, Compound 2I...)
Affinity DataIC50: 0.75nMAssay Description:Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Korea Institute of Science and Technology

US Patent
LigandPNGBDBM435718(US10570155, Compound 2II | US11332479, Compound 2I...)
Affinity DataIC50: 0.0400nMAssay Description:Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Korea Institute of Science and Technology

US Patent
LigandPNGBDBM435718(US10570155, Compound 2II | US11332479, Compound 2I...)
Affinity DataIC50: 0.670nMAssay Description:Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [696-1022,L858R](Human)
Korea Institute of Science and Technology

US Patent
LigandPNGBDBM435718(US10570155, Compound 2II | US11332479, Compound 2I...)
Affinity DataIC50: 0.75nMAssay Description:Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details
Go to US Patent