BDBM435706 (2R,3S,4R,5R)-2-(4-chloro-2- (hydroxymethyl)benzyl)-3-methyl-5-(4- methyl-7H-pyrrolo[2,3-d]pyrimidin-7- yl)tetrahydrofuran-3,4-diol::US10570140, Example 64::US11078205, Example 64

SMILES Cc1ncnc2n(ccc12)[C@@H]1O[C@H](Cc2ccc(Cl)cc2CO)[C@@](C)(O)[C@H]1O

InChI Key InChIKey=ZGTFXCLQCUFVNG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 435706   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM435706(US10570140, Example 64 | (2R,3S,4R,5R)-2-(4-chloro...)
Affinity DataIC50: 1.61E+3nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
Go to US Patent

TargetProtein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM435706(US10570140, Example 64 | (2R,3S,4R,5R)-2-(4-chloro...)
Affinity DataIC50: 1.61E+3nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
Go to US Patent