BDBM435703 (2R,3S,4R,5R)-2-((R)-(4-fluoro-3- (trifluorometh- yl)phenyl)(hydroxy)methyl)- 3-methyl-5-(4-methyl-7H-pyrrolo[2,3- d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol::US10570140, Example 61::US11078205, Example 61::US11208416, Example 61

SMILES Cc1ncnc2n(ccc12)[C@@H]1O[C@H]([C@H](O)c2ccc(F)c(c2)C(F)(F)F)[C@@](C)(O)[C@H]1O

InChI Key InChIKey=YUOKSWIONSHHRB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 435703   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM435703(US10570140, Example 61 | (2R,3S,4R,5R)-2-((R)-(4-f...)
Affinity DataIC50: 16nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
Go to US Patent

TargetProtein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM435703(US10570140, Example 61 | (2R,3S,4R,5R)-2-((R)-(4-f...)
Affinity DataIC50: 16nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
Go to US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM435703(US10570140, Example 61 | (2R,3S,4R,5R)-2-((R)-(4-f...)
Affinity DataIC50: 16nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2022
Entry Details
Go to US Patent