BDBM4345 (2E)-2-cyano-3-[4-(dimethylamino)phenyl]prop-2-enoic acid::benzylidenemalononitrile (BMN) deriv. 29

SMILES CN(C)c1ccc(\C=C(/C#N)C(O)=O)cc1

InChI Key InChIKey=CXZXLLVNQYUMAW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 4345   

TargetEpidermal growth factor receptor(Human)
Hebrew University of Jerusalem

LigandPNGBDBM4345((2E)-2-cyano-3-[4-(dimethylamino)phenyl]prop-2-eno...)
Affinity DataIC50: 1.40E+6nMAssay Description:The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMonocarboxylate transporter 1(Rat)
Medical School Duluth

Curated by ChEMBL
LigandPNGBDBM4345((2E)-2-cyano-3-[4-(dimethylamino)phenyl]prop-2-eno...)
Affinity DataIC50: 140nMAssay Description:Inhibition of MCT1-mediated lactate transport in rat RBE4 cells incubated for 15 mins by [14C]-lactate uptake assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed