BDBM4341 2-[(3,4,5-trihydroxyphenyl)methylidene]propanedinitrile::benzylidenemalononitrile (BMN) deriv. 25

SMILES [#8]-c1cc(\[#6]=[#6](/C#N)C#N)cc(-[#8])c1-[#8]

InChI Key InChIKey=RIZNVWODMUYYSK-UHFFFAOYSA-N

Data  1 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 4341   

TargetAutoinducer 2-binding periplasmic protein LuxP(Vibrio harveyi)
Georgia State University

Curated by ChEMBL
LigandPNGBDBM4341(2-[(3,4,5-trihydroxyphenyl)methylidene]propanedini...)
Affinity DataIC50: 3.00E+3nMAssay Description:Antagonist activity at LuxP receptor in Vibrio harveyi MM32 assessed as inhibition of autoinducer-2-mediated quorum sensing after 3 to 4 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 1(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM4341(2-[(3,4,5-trihydroxyphenyl)methylidene]propanedini...)
Affinity DataIC50: 3.33E+5nMAssay Description:Inhibition of human recombinant Tdp1 assessed as conversion of 14-mer 5'-32P-labeled 3'-phosphotyrosyl DNA substrate N14Y to 14-mer 5'-32P-labeled 3'...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM4341(2-[(3,4,5-trihydroxyphenyl)methylidene]propanedini...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibitory activity against protein tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEpidermal growth factor receptor(Human)
Hebrew University of Jerusalem

LigandPNGBDBM4341(2-[(3,4,5-trihydroxyphenyl)methylidene]propanedini...)
Affinity DataKi:  1.00E+3nM IC50: 3.00E+3nMAssay Description:The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed