BDBM433388 BDBM433391::US10562850, Compound 36d::US10562850, Compound 37d::US11066360, Compound 37d

SMILES CO[C@@H]1C[C@@H](N(C1)C(=O)Nc1ccc(Cl)cn1)C(=O)Nc1cc(ccc1F)C(N)(CCC1CC1)c1ccccn1

InChI Key InChIKey=HMKGSFLIMYOEKX-UHFFFAOYSA-N

Data  4 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 433388   

TargetPlasma kallikrein(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM433388(US10562850, Compound 36d | US10562850, Compound 37...)
Affinity DataIC50: 50nMAssay Description:Inhibition of human plasma kallikrein using H-D-Pro-Phe-Arg-p-nitroaniline as substrate assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetPlasma kallikrein(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM433388(US10562850, Compound 36d | US10562850, Compound 37...)
Affinity DataKi: <50nMAssay Description:The effect of compounds of the invention on human plasma kallikrein activity was determined using the chromogenic substrates. In these experiments, 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
Go to US Patent

TargetPlasma kallikrein(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM433388(US10562850, Compound 36d | US10562850, Compound 37...)
Affinity DataKi: <50nMAssay Description:The effect of compounds of the invention on human plasma kallikrein activity was determined using the chromogenic substrates (DiaPharma Group, Inc., ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
Go to US Patent

TargetPlasma kallikrein(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM433388(US10562850, Compound 36d | US10562850, Compound 37...)
Affinity DataKi: >100nMAssay Description:The effect of compounds of the invention on human plasma kallikrein activity was determined using the chromogenic substrates. In these experiments, 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
Go to US Patent

TargetPlasma kallikrein(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM433388(US10562850, Compound 36d | US10562850, Compound 37...)
Affinity DataKi: >100nMAssay Description:The effect of compounds of the invention on human plasma kallikrein activity was determined using the chromogenic substrates (DiaPharma Group, Inc., ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
Go to US Patent