BDBM431939 US10576064, Example I-5

SMILES CCOc1cccc(CN2[C@H]3CCNC(=O)[C@H]3[C@H](c3cccc(Cl)c3F)[C@]22C(=O)Nc3cc(Cl)ccc23)c1

InChI Key InChIKey=BJHMTGTXPKRGKQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 431939   

TargetE3 ubiquitin-protein ligase Mdm2 [23-127](Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM431939(US10576064, Example I-5)
Affinity DataIC50: 17nMAssay Description:This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
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