BDBM430048 (R)-5-(4-(2-(4-chlorobenzyl)pyrrolidin-1-yl)piperidin-1-yl)-4H-1,2,4-triazol-3-amine ::US10538508, Example 24

SMILES Nc1nnc([nH]1)N1CCC(CC1)N1CCC[C@@H]1c1cccc(Cl)c1

InChI Key InChIKey=JKMBBWNJOLXAPR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 430048   

TargetAcidic mammalian chitinase(Human)
Oncoarendi Therapeutics

US Patent
LigandPNGBDBM430048(US10538508, Example 24 | (R)-5-(4-(2-(4-chlorobenz...)
Affinity DataIC50: 100nMAssay Description:An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2020
Entry Details
Go to US Patent

TargetChitotriosidase-1(Human)
Oncoarendi Therapeutics

US Patent
LigandPNGBDBM430048(US10538508, Example 24 | (R)-5-(4-(2-(4-chlorobenz...)
Affinity DataIC50: 100nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2020
Entry Details
Go to US Patent