BDBM429492 1-Methyl-N-(thiophen-2-ylsulfonyl)-3-(4-(trifluoromethyl)phenyl)-1H-indole-6-carboxamide::US10550080, Example 20

SMILES Cn1cc(-c2ccc(cc2)C(F)(F)F)c2ccc(cc12)C(=O)NS(=O)(=O)c1cccs1

InChI Key InChIKey=NMUJXYWKRSUNQO-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 429492   

TargetSodium channel protein type 9 subunit alpha(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM429492(1-Methyl-N-(thiophen-2-ylsulfonyl)-3-(4-(trifluoro...)
Affinity DataIC50: 419nMAssay Description:Ion Works Barracuda population patch clamp (PPC). PPC measurements were performed using an IonWorks Barracuda instrument (Molecular Devices Corporati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM429492(1-Methyl-N-(thiophen-2-ylsulfonyl)-3-(4-(trifluoro...)
Affinity DataIC50: 361nMAssay Description:hNaV1.7 binding affinities were determined with a filtration binding assay using purified membranes from HEK293 cells stably expressing hNaV1.7. HEK2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM429492(1-Methyl-N-(thiophen-2-ylsulfonyl)-3-(4-(trifluoro...)
Affinity DataIC50: 3.86E+3nMAssay Description:Ion Works Barracuda population patch clamp (PPC). PPC measurements were performed using an IonWorks Barracuda instrument (Molecular Devices Corporati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM429492(1-Methyl-N-(thiophen-2-ylsulfonyl)-3-(4-(trifluoro...)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells after 600 secs at -50 mV holding potential by ion works barracuda population patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM429492(1-Methyl-N-(thiophen-2-ylsulfonyl)-3-(4-(trifluoro...)
Affinity DataIC50: 420nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells after 600 secs at -60 mV holding potential by ion works barracuda population patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed