BDBM429488 3-(3-Isopropylphenyl)-1-methyl-N-(methylsulfonyl)-1H-indole-6-carboxamide::US10550080, Example 16

SMILES CC(C)c1cccc(c1)-c1cn(C)c2cc(ccc12)C(=O)NS(C)(=O)=O

InChI Key InChIKey=YEEURBDOVJLKFT-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 429488   

TargetSodium channel protein type 9 subunit alpha(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM429488(3-(3-Isopropylphenyl)-1-methyl-N-(methylsulfonyl)-...)
Affinity DataIC50: 427nMAssay Description:Ion Works Barracuda population patch clamp (PPC). PPC measurements were performed using an IonWorks Barracuda instrument (Molecular Devices Corporati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM429488(3-(3-Isopropylphenyl)-1-methyl-N-(methylsulfonyl)-...)
Affinity DataIC50: 217nMAssay Description:hNaV1.7 binding affinities were determined with a filtration binding assay using purified membranes from HEK293 cells stably expressing hNaV1.7. HEK2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM429488(3-(3-Isopropylphenyl)-1-methyl-N-(methylsulfonyl)-...)
Affinity DataIC50: 3.00E+4nMAssay Description:Ion Works Barracuda population patch clamp (PPC). PPC measurements were performed using an IonWorks Barracuda instrument (Molecular Devices Corporati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
Go to US Patent