BDBM429465 ALP-POS-c59291d4-1::CVD-0006350::ML300-based SC inhibitor 7::acs.jmedchem.1c00409_ST.38::med.21724, Compound 137

SMILES O=C(Cn1nnc2ccccc12)N(Cc1ccsc1)c1ccc(cc1)-c1ccccc1

InChI Key InChIKey=BRLBTOJQLXGOHO-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 429465   

TargetReplicase polyprotein 1ab(SARS-CoV)
University of Bonn

LigandPNGBDBM429465(med.21724, Compound 137 | ML300-based SC inhibitor...)
Affinity DataIC50: 510nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Israel Institution of Biological Research

LigandPNGBDBM429465(med.21724, Compound 137 | ML300-based SC inhibitor...)
Affinity DataIC50: 5.32E+3nMAssay Description:Compounds were seeded into assay-ready plates (Greiner 384 low volume, cat 784900) using an Echo 555 acoustic dispenser, and DMSO was back-filled for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2021
Entry Details Article

TargetSerine protease 1(Human)
Israel Institution of Biological Research

LigandPNGBDBM429465(med.21724, Compound 137 | ML300-based SC inhibitor...)
Affinity DataIC50: 9.90E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2021
Entry Details Article

TargetReplicase polyprotein 1ab(SARS-CoV)
University of Bonn

LigandPNGBDBM429465(med.21724, Compound 137 | ML300-based SC inhibitor...)
Affinity DataIC50: 1.68E+4nMAssay Description:The protease activity and subsequent 10-point IC50 curves were spectroscopically determined using a scaled down, end point assay adapted from a previ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Israel Institution of Biological Research

LigandPNGBDBM429465(med.21724, Compound 137 | ML300-based SC inhibitor...)
Affinity DataIC50: 3.12E+4nMAssay Description:The protease activity and subsequent 10-point IC50 curves were spectroscopically determined using a scaled down, end point assay adapted from a previ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(SARS-CoV)
University of Bonn

LigandPNGBDBM429465(med.21724, Compound 137 | ML300-based SC inhibitor...)
Affinity DataIC50: 51nMAssay Description:This is a review article. Please point to the original journal.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2022
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Israel Institution of Biological Research

LigandPNGBDBM429465(med.21724, Compound 137 | ML300-based SC inhibitor...)
Affinity DataIC50: 5.32E+3nMAssay Description:Compounds were seeded into assay-ready plates (Greiner 384 low volume, cat. no. 784900) using an Echo 555 acoustic dispenser, and dimethyl sulfoxide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(SARS-CoV)
University of Bonn

LigandPNGBDBM429465(med.21724, Compound 137 | ML300-based SC inhibitor...)
Affinity DataIC50: 5.10E+4nMAssay Description:Inhibition of SARS-CoV-1 MProMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed