BDBM426612 N1,N4-bis(2-(2-(2-(2-(3-((S or R)-6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenylsulfonamido)ethoxy)ethoxy)ethoxy)ethyl)-2,3-dihydroxysuccinamide::US10543207, Example 224

SMILES CN1C[C@@H](c2cccc(c2)S(=O)(=O)NCCOCCOCCOCCN=[N+]=[N-])c2cc(Cl)cc(Cl)c2C1

InChI Key InChIKey=CFVAWZOLEXOSMW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 426612   

TargetSodium/hydrogen exchanger 3(Rat)
Ardelyx

US Patent
LigandPNGBDBM426612(N1,N4-bis(2-(2-(2-(2-(3-((S or R)-6,8-dichloro-2-m...)
Affinity DataIC50: 100nMAssay Description:Rat NHE-3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensitive dye method originally reported by Tsien (Proc. Nat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2020
Entry Details
Go to US Patent