BDBM426530 2-(6-chloro-4-(3-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)quinazolin-2-yl)guanidine::US10543207, Example 68

SMILES [#7]\[#6](-[#7])=[#7]\c1nc(-c2cccc(c2)-[#7]-2-[#6]-[#6]-[#7](-[#6]-[#6]-[#8])-[#6]-[#6]-2)c2cc(Cl)ccc2n1

InChI Key InChIKey=RSCGALQMZLSOOI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 426530   

TargetSodium/hydrogen exchanger 3(Rat)
Ardelyx

US Patent
LigandPNGBDBM426530(2-(6-chloro-4-(3-(4-(2-hydroxyethyl)piperazin-1-yl...)
Affinity DataIC50: 316nMAssay Description:Rat NHE-3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensitive dye method originally reported by Tsien (Proc. Nat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2020
Entry Details
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