BDBM426529 2-(4-(3-(4-(3-guanidinopropyl)piperazin-1-yl)phenyl)-6-chloroquinazolin-2-yl)guanidine::US10543207, Example 67

SMILES [#7]\[#6](-[#7])=[#7]\[#6]-[#6]-[#6]-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-1)-c1cccc(c1)-c1nc(\[#7]=[#6](\[#7])-[#7])nc2ccc(Cl)cc12

InChI Key InChIKey=ZTJLHOVRZUIHFP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 426529   

TargetSodium/hydrogen exchanger 3(Rat)
Ardelyx

US Patent
LigandPNGBDBM426529(2-(4-(3-(4-(3-guanidinopropyl)piperazin-1-yl)pheny...)
Affinity DataIC50: 316nMAssay Description:Rat NHE-3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensitive dye method originally reported by Tsien (Proc. Nat...More data for this Ligand-Target Pair
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Date in BDB:
11/1/2020
Entry Details
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