BDBM426525 N,N′-(13-oxo-3,6,9,17,20,23-hexaoxa-12,14-diazapentacosane-1,25-diyl)bis[(E)-N-(diaminomethylene)-3-(3,5-difluoro-4-(4-sulfamoylphenoxy)phenyl)-2-methylacrylamide]::US10543207, Example 46

SMILES CCOC(=O)C(\C)=C\c1cc(F)c(Oc2ccc(cc2)S(=O)(=O)NCCOCCOCCOCCNC(=O)NCCOCCOCCOCCNS(=O)(=O)c2ccc(Oc3c(F)cc(\C=C(/C)C(=O)OCC)cc3F)cc2)c(F)c1

InChI Key InChIKey=QOGPWCOLNPEBJO-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 426525   

TargetSodium/hydrogen exchanger 3(Rat)
Ardelyx

US Patent
LigandPNGBDBM426525(N,N′-(13-oxo-3,6,9,17,20,23-hexaoxa-12,14-di...)
Affinity DataIC50: 316nMAssay Description:Rat NHE-3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensitive dye method originally reported by Tsien (Proc. Nat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2020
Entry Details
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