BDBM425083 N-((S)-5-((1R,2S)-2-(4- fluorophenyl)cyclopropylamino)-1-(4- methylpiperazin-1-yl)-1-oxopentan-2-yl)-4- (1H-1,2,3-triazol-1-yl)benzamide::US10519118, Example 158::US11230534, Example 158

SMILES CN1CCN(CC1)C(=O)[C@H](CCCN[C@@H]1C[C@H]1c1ccc(F)cc1)NC(=O)c1ccc(cc1)-n1ccnn1

InChI Key InChIKey=KQKBMHGOHXOHTD-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 425083   

TargetLysine-specific histone demethylase 1A(Human)
Imago Biosciences

US Patent
LigandPNGBDBM425083(US10519118, Example 158 | N-((S)-5-((1R,2S)-2-(4- ...)
Affinity DataIC50: 1.00E+4nMAssay Description:Briefly, bulk histones, histone peptides or nucleosomes are incubated with purified human recombinant KDM1A, in the histone demethylase activity (HDM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2020
Entry Details
Go to US Patent

TargetLysine-specific histone demethylase 1A(Human)
Imago Biosciences

US Patent
LigandPNGBDBM425083(US10519118, Example 158 | N-((S)-5-((1R,2S)-2-(4- ...)
Affinity DataIC50: 1.00E+4nMAssay Description:The KDM1A demethylase enzyme activity can obtained from mammalian cells or tissues expressing KDM1A from an endogenous or recombinant gene and purifi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2022
Entry Details
Go to US Patent

TargetLysine-specific histone demethylase 1A(Human)
Imago Biosciences

US Patent
LigandPNGBDBM425083(US10519118, Example 158 | N-((S)-5-((1R,2S)-2-(4- ...)
Affinity DataIC50: 57nMAssay Description:Inhibition of LSD1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Imago Biosciences

US Patent
LigandPNGBDBM425083(US10519118, Example 158 | N-((S)-5-((1R,2S)-2-(4- ...)
Affinity DataIC50: 10nMAssay Description:Inhibition of LSD1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed