BDBM421831 3-((1-(4-fluorobenzoyl)-4-hydroxypiperidin-4-yl)methyl)-8-(4-fluorophenoxy)quinazolin-4(3H)-one::US10508098, Example I-10::US10513507, Example I-10::US10836741, Example I-10

SMILES OC1(Cn2cnc3c(Oc4ccc(F)cc4)cccc3c2=O)CCN(CC1)C(=O)c1ccc(F)cc1

InChI Key InChIKey=VKKARVNKTHWRPC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 421831   

TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
Forma Therapeutics

US Patent
LigandPNGBDBM421831(US10508098, Example I-10 | US10513507, Example I-1...)
Affinity DataIC50: 5.50E+3nMAssay Description:Each assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
Go to US Patent

TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
Forma Therapeutics

US Patent
LigandPNGBDBM421831(US10508098, Example I-10 | US10513507, Example I-1...)
Affinity DataIC50: 5.50E+3nMAssay Description:Each assay was performed in a final volume of 15 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2020
Entry Details
Go to US Patent

TargetUbiquitin carboxyl-terminal hydrolase 7 [208-1102](Human)
Valo Early Discovery

US Patent
LigandPNGBDBM421831(US10508098, Example I-10 | US10513507, Example I-1...)
Affinity DataIC50: 5.50E+3nMAssay Description:Each assay was performed in a final volume of 15 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
Go to US Patent