BDBM421825 N-(3-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)methyl)-4-oxo-3,4-dihydroquinazolin-7-yl)acetamide::US10508098, Example I-4::US10513507, Example I-4::US10836741, Example I-4

SMILES CC(CC(=O)N1CCC(O)(Cn2cnc3cc(NC(C)=O)ccc3c2=O)CC1)c1ccccc1

InChI Key InChIKey=ICJLQZBRRUPVTE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 421825   

TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
Forma Therapeutics

US Patent
LigandPNGBDBM421825(US10508098, Example I-4 | US10513507, Example I-4 ...)
Affinity DataIC50: 200nMAssay Description:Each assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
Go to US Patent

TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
Forma Therapeutics

US Patent
LigandPNGBDBM421825(US10508098, Example I-4 | US10513507, Example I-4 ...)
Affinity DataIC50: 200nMAssay Description:Each assay was performed in a final volume of 15 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2020
Entry Details
Go to US Patent

TargetUbiquitin carboxyl-terminal hydrolase 7 [208-1102](Human)
Valo Early Discovery

US Patent
LigandPNGBDBM421825(US10508098, Example I-4 | US10513507, Example I-4 ...)
Affinity DataIC50: 200nMAssay Description:Each assay was performed in a final volume of 15 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
Go to US Patent