BDBM421657 N-hydroxy-3-((1-(2-methoxyethyl)-6- phenyl-5-(trifluoromethyl)-1H- benzo[d]imidazol-2-yl)amino)benzamide::US10508088, Example 20-1::US10538496, Compound 20-1

SMILES COCCn1c(Nc2cccc(c2)C(=O)NO)nc2cc(c(cc12)-c1ccccc1)C(F)(F)F

InChI Key InChIKey=OVYRSNZOBUXFBJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 421657   

TargetHistone deacetylase 11(Human)
Forma Therapeutics

US Patent
LigandPNGBDBM421657(US10538496, Compound 20-1 | US10508088, Example 20...)
Affinity DataIC50: 500nMAssay Description:This example describes in vitro inhibition properties of exemplary HDAC11 inhibitors for various HDACs. HDAC inhibition assays were performed using a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
Go to US Patent

TargetHistone deacetylase 11(Human)
Forma Therapeutics

US Patent
LigandPNGBDBM421657(US10538496, Compound 20-1 | US10508088, Example 20...)
Affinity DataIC50: 500nMAssay Description:The probe binding HDAC11 assay was performed using a time resolved fluorescence (TRF) assay format. Recombinant N-terminal GST tag full-length human ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2020
Entry Details
Go to US Patent