BDBM421656 3-((5-cyano-1-(2-methoxyethyl)-6- (trifluoromethyl)-1H-benzo[d]imidazol-2- yl)amino)-N-hydroxybenzamide::US10508088, Example 19-1::US10538496, Compound 26-1

SMILES COCCn1c(Nc2cccc(c2)C(=O)NO)nc2cc(C#N)c(cc12)C(F)(F)F

InChI Key InChIKey=VHHDYJQRIOMRIA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 421656   

TargetHistone deacetylase 11(Human)
Forma Therapeutics

US Patent
LigandPNGBDBM421656(US10538496, Compound 26-1 | US10508088, Example 19...)
Affinity DataIC50: 500nMAssay Description:This example describes in vitro inhibition properties of exemplary HDAC11 inhibitors for various HDACs. HDAC inhibition assays were performed using a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
Go to US Patent

TargetHistone deacetylase 11(Human)
Forma Therapeutics

US Patent
LigandPNGBDBM421656(US10538496, Compound 26-1 | US10508088, Example 19...)
Affinity DataIC50: 500nMAssay Description:The probe binding HDAC11 assay was performed using a time resolved fluorescence (TRF) assay format. Recombinant N-terminal GST tag full-length human ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2020
Entry Details
Go to US Patent

TargetHistone deacetylase 11(Human)
Forma Therapeutics

US Patent
LigandPNGBDBM421656(US10538496, Compound 26-1 | US10508088, Example 19...)
Affinity DataIC50: 1.00E+3nMAssay Description:The probe binding HDAC11 assay was performed using a time resolved fluorescence (TRF) assay format. Recombinant N-terminal GST tag full-length human ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2020
Entry Details
Go to US Patent