BDBM420293 alpha-ketoamide inhibitor 13a

SMILES CC(C)(C)OC(=O)Nc1cccn([C@@H](CC2CCCCC2)C(=O)N[C@@H](C[C@@H]2CCNC2=O)C(=O)C(=O)NC2CC2)c1=O

InChI Key InChIKey=JYNPCEUBSGNIIR-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 420293   

TargetReplicase polyprotein 1ab [3264-3569](2019-nCoV)
University of Lubeck

LigandPNGBDBM420293(alpha-ketoamide inhibitor 13a)
Affinity DataIC50: 2.39E+3nMAssay Description:A fluorescent substrate harboring the cleavage site (indicated by the arrow, ↓) of SARS-CoV-2 Mpro(Dabcyl-KTSAVLQ↓SGFRKM-E(Edans)-NH2; GL...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/21/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(SARS-CoV)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM420293(alpha-ketoamide inhibitor 13a)
Affinity DataIC50: 2.39E+3nMAssay Description:Inhibition of SARS-CoV-1 MProMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM420293(alpha-ketoamide inhibitor 13a)
Affinity DataIC50: 2.39E+3nMAssay Description:Inhibition of SARS-CoV-2 Main protease by FRET assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM420293(alpha-ketoamide inhibitor 13a)
Affinity DataIC50: 2.39E+3nMAssay Description:Inhibition of recombinant SARS-COV2 main proteaseMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed