BDBM420283 alpha-ketoamide inhibitor 11r::med.21724, Compound 64

SMILES O=C(N[C@@H](CC1CCCCC1)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(=O)C(=O)NCc1ccccc1)\C=C\c1ccccc1

InChI Key InChIKey=QTGORSKTHIBLJT-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 420283   

TargetReplicase polyprotein 1ab [3264-3569](2019-nCoV)
University of Lubeck

LigandPNGBDBM420283(med.21724, Compound 64 | alpha-ketoamide inhibitor...)
Affinity DataIC50: 180nMAssay Description:A fluorescent substrate harboring the cleavage site (indicated by the arrow, ↓) of SARS-CoV-2 Mpro(Dabcyl-KTSAVLQ↓SGFRKM-E(Edans)-NH2; GL...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/21/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(SARS-CoV)
University of Bonn

LigandPNGBDBM420283(med.21724, Compound 64 | alpha-ketoamide inhibitor...)
Affinity DataIC50: 710nMAssay Description:This is a review article.More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Bonn

LigandPNGBDBM420283(med.21724, Compound 64 | alpha-ketoamide inhibitor...)
Affinity DataIC50: 160nMAssay Description:This is a review article.More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Bonn

LigandPNGBDBM420283(med.21724, Compound 64 | alpha-ketoamide inhibitor...)
Affinity DataIC50: 710nMAssay Description:Inhibition of SARS CoV-2 3CL proteaseMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(SARS-CoV)
University of Bonn

LigandPNGBDBM420283(med.21724, Compound 64 | alpha-ketoamide inhibitor...)
Affinity DataIC50: 710nMAssay Description:Inhibition of SARS-CoV-1 MProMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Bonn

LigandPNGBDBM420283(med.21724, Compound 64 | alpha-ketoamide inhibitor...)
Affinity DataIC50: 180nMAssay Description:Inhibition of SARS-CoV-2 Main protease by FRET assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Bonn

LigandPNGBDBM420283(med.21724, Compound 64 | alpha-ketoamide inhibitor...)
Affinity DataIC50: 180nMAssay Description:Inhibition of SARS-CoV-2 Main protease transfected in Escherichia coli BL21-Gold (DE3) using (Dabcyl-KTSAVLQSGFRKM-E(Edans)-NH2 as substrate by FRET ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Bonn

LigandPNGBDBM420283(med.21724, Compound 64 | alpha-ketoamide inhibitor...)
Affinity DataIC50: 180nMAssay Description:Inhibition of recombinant SARS-COV2 main proteaseMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed