BDBM420078 US10487086, Example I-72::US11136327, Example I-72

SMILES COC(=O)Nc1ccc2-c3c[nH]c(n3)[C@H](CCCC[C@@H](Nc2c1)C(F)F)NC(=O)\C=C\c1cc(Cl)ccc1-n1cnnn1

InChI Key InChIKey=WLDKJYDPGYMYML-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 420078   

TargetCoagulation factor XI(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM420078(US10487086, Example I-72 | US11136327, Example I-7...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of recombinant human activated coagulation factor XI using pyro-Glu-Pro-Arg-pNA as substrate by spectrophotometryMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetCoagulation factor XI(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM420078(US10487086, Example I-72 | US11136327, Example I-7...)
Affinity DataKi:  289nMAssay Description:The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/20/2020
Entry Details
Go to US Patent

TargetCoagulation factor XI(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM420078(US10487086, Example I-72 | US11136327, Example I-7...)
Affinity DataKi:  289nMAssay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 145 mM NaCl, 5 mM KCl, and 0.1% PEG 8000 (polyethylene glycol; JT Bake...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent