BDBM419842 US10464919, Example 180

SMILES Fc1cc(CN2CCN(CC2)c2ccc(nc2)C#N)cc2[nH]c(=O)c3CCCNc3c12

InChI Key InChIKey=RAPGQTWOPCNSEJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 419842   

TargetPoly [ADP-ribose] polymerase 1(Human)
Je Il Pharmaceutical

US Patent
LigandPNGBDBM419842(US10464919, Example 180)
Affinity DataIC50: 5.27nMAssay Description:The PARP-1 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of a kit (cat. 80551) p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2020
Entry Details
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TargetNon-receptor tyrosine-protein kinase TNK1(Human)
Je Il Pharmaceutical

US Patent
LigandPNGBDBM419842(US10464919, Example 180)
Affinity DataIC50: 8.05nMAssay Description:The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2020
Entry Details
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TargetActivated CDC42 kinase 1(Human)
Je Il Pharmaceutical

US Patent
LigandPNGBDBM419842(US10464919, Example 180)
Affinity DataIC50: 2.12nMAssay Description:The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2020
Entry Details
Go to US Patent