BDBM419740 US10464919, Example 78

SMILES Fc1cc(ccc1C(=O)NC1CC1)N1CCN(Cc2ccc3c4NCCCc4c(=O)[nH]c3c2)CC1

InChI Key InChIKey=UOAHTPZUUUBPBK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 419740   

TargetPoly [ADP-ribose] polymerase 1(Human)
Je Il Pharmaceutical

US Patent
LigandPNGBDBM419740(US10464919, Example 78)
Affinity DataIC50: 6.64nMAssay Description:The PARP-1 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of a kit (cat. 80551) p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2020
Entry Details
Go to US Patent

TargetNon-receptor tyrosine-protein kinase TNK1(Human)
Je Il Pharmaceutical

US Patent
LigandPNGBDBM419740(US10464919, Example 78)
Affinity DataIC50: 11nMAssay Description:The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2020
Entry Details
Go to US Patent

TargetActivated CDC42 kinase 1(Human)
Je Il Pharmaceutical

US Patent
LigandPNGBDBM419740(US10464919, Example 78)
Affinity DataIC50: 1.87nMAssay Description:The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2020
Entry Details
Go to US Patent