BDBM418862 N-[2-({[2-({4-[(1R)-1- aminoethyl]phenyl}amino)-5- (trifluoromethyl)pyrimidin-4- yl]amino}methyl)phenyl]-N- methylmethanesulfonamide (362), hydrochloride salt::US10450297, Example 362::US10450297, Example 363

SMILES C[C@H](N)c1ccc(Nc2ncc(c(NCc3ccccc3N(C)S(C)(=O)=O)n2)C(F)(F)F)cc1

InChI Key InChIKey=LOAIMLKTHJKSKY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 418862   

TargetFocal adhesion kinase 1 [410-689](Human)
Pfizer

US Patent
LigandPNGBDBM418862(US10450297, Example 362 | N-[2-({[2-({4-[(1R)-1- a...)
Affinity DataIC50: 0.595nMAssay Description:The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details
Go to US Patent

TargetFocal adhesion kinase 1 [410-689](Human)
Pfizer

US Patent
LigandPNGBDBM418862(US10450297, Example 362 | N-[2-({[2-({4-[(1R)-1- a...)
Affinity DataIC50: 0.595nMAssay Description:The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details
Go to US Patent