BDBM418464 7-Methoxy-1-(3-methoxy- pyridin-4-yl)-3-methyl-8- (1H-pyrazol-4-yl)-1,3- dihydroimidazo[4,5-c]- quinolin-2-one::US10457677, Example 32::US10745399, Example 32::US10975075, Example 32::US11608338, Example 32

SMILES COc1cnccc1-n1c2c(cnc3cc(OC)c(cc23)-c2cn[nH]c2)n(C)c1=O

InChI Key InChIKey=HNKXQGJPRQDAFP-UHFFFAOYSA-N

Data  23 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 23 hits for monomerid = 418464   

TargetSerine-protein kinase ATM(Human)
Merck Patent

US Patent
LigandPNGBDBM418464(7-Methoxy-1-(3-methoxy- pyridin-4-yl)-3-methyl-8- ...)
Affinity DataIC50: 10nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2021
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Merck Patent

US Patent
LigandPNGBDBM418464(7-Methoxy-1-(3-methoxy- pyridin-4-yl)-3-methyl-8- ...)
Affinity DataIC50: 1.00E+4nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent

LigandPNGBDBM418464(7-Methoxy-1-(3-methoxy- pyridin-4-yl)-3-methyl-8- ...)
Affinity DataIC50: 3.00E+4nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent

LigandPNGBDBM418464(7-Methoxy-1-(3-methoxy- pyridin-4-yl)-3-methyl-8- ...)
Affinity DataIC50: 3.00E+4nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent

LigandPNGBDBM418464(7-Methoxy-1-(3-methoxy- pyridin-4-yl)-3-methyl-8- ...)
Affinity DataIC50: 3.00E+4nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent

TargetSerine-protein kinase ATM(Human)
Merck Patent

US Patent
LigandPNGBDBM418464(7-Methoxy-1-(3-methoxy- pyridin-4-yl)-3-methyl-8- ...)
Affinity DataIC50: 10nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent

TargetSerine-protein kinase ATM(Human)
Merck Patent

US Patent
LigandPNGBDBM418464(7-Methoxy-1-(3-methoxy- pyridin-4-yl)-3-methyl-8- ...)
Affinity DataIC50: 10nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent

TargetSerine-protein kinase ATM(Human)
Merck Patent

US Patent
LigandPNGBDBM418464(7-Methoxy-1-(3-methoxy- pyridin-4-yl)-3-methyl-8- ...)
Affinity DataIC50: 10nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2021
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Merck Patent

US Patent
LigandPNGBDBM418464(7-Methoxy-1-(3-methoxy- pyridin-4-yl)-3-methyl-8- ...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2021
Entry Details
Go to US Patent

LigandPNGBDBM418464(7-Methoxy-1-(3-methoxy- pyridin-4-yl)-3-methyl-8- ...)
Affinity DataIC50: 3.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2021
Entry Details
Go to US Patent

LigandPNGBDBM418464(7-Methoxy-1-(3-methoxy- pyridin-4-yl)-3-methyl-8- ...)
Affinity DataIC50: 3.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2021
Entry Details
Go to US Patent

LigandPNGBDBM418464(7-Methoxy-1-(3-methoxy- pyridin-4-yl)-3-methyl-8- ...)
Affinity DataIC50: 3.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2021
Entry Details
Go to US Patent

TargetSerine-protein kinase ATM(Human)
Merck Patent

US Patent
LigandPNGBDBM418464(7-Methoxy-1-(3-methoxy- pyridin-4-yl)-3-methyl-8- ...)
Affinity DataIC50: 10nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Merck Patent

US Patent
LigandPNGBDBM418464(7-Methoxy-1-(3-methoxy- pyridin-4-yl)-3-methyl-8- ...)
Affinity DataIC50: 1.00E+4nMAssay Description:mTOR (human) was incubated with 50 mM HEPES pH 7.5, 1 mM EGTA, 0.01% Tween 20, 2 mg/ml of the substrate, 3 mM MnCl2 and [γ-33P-ATP] (specific ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2021
Entry Details
Go to US Patent

LigandPNGBDBM418464(7-Methoxy-1-(3-methoxy- pyridin-4-yl)-3-methyl-8- ...)
Affinity DataIC50: 3.00E+4nMAssay Description:PI3K (p120γ) (human) was incubated in an assay buffer comprising 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ne...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2021
Entry Details
Go to US Patent

LigandPNGBDBM418464(7-Methoxy-1-(3-methoxy- pyridin-4-yl)-3-methyl-8- ...)
Affinity DataIC50: 3.00E+4nMAssay Description:PI3K p110δ/p85α (human) was incubated in an assay buffer comprising 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentrati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2021
Entry Details
Go to US Patent

LigandPNGBDBM418464(7-Methoxy-1-(3-methoxy- pyridin-4-yl)-3-methyl-8- ...)
Affinity DataIC50: 3.00E+4nMAssay Description:PI3K p110α/p85α (human) was incubated in an assay buffer comprising 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentrati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2021
Entry Details
Go to US Patent

TargetSerine-protein kinase ATM(Human)
Merck Patent

US Patent
LigandPNGBDBM418464(7-Methoxy-1-(3-methoxy- pyridin-4-yl)-3-methyl-8- ...)
Affinity DataIC50: 10nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2021
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Merck Patent

US Patent
LigandPNGBDBM418464(7-Methoxy-1-(3-methoxy- pyridin-4-yl)-3-methyl-8- ...)
Affinity DataIC50: 1.00E+4nMAssay Description:mTOR (human) was incubated with 50 mM HEPES pH 7.5, 1 mM EGTA, 0.01% Tween 20, 2 mg/ml of the substrate, 3 mM MnCl2 and [γ-33P-ATP] (specific ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
Go to US Patent

LigandPNGBDBM418464(7-Methoxy-1-(3-methoxy- pyridin-4-yl)-3-methyl-8- ...)
Affinity DataIC50: 3.00E+4nMAssay Description:PI3K (p120γ) (human) was incubated in an assay buffer comprising 10 μM phosphati-dylinositol 4,5-bisphosphate and MgATP (concentration as n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
Go to US Patent

LigandPNGBDBM418464(7-Methoxy-1-(3-methoxy- pyridin-4-yl)-3-methyl-8- ...)
Affinity DataIC50: 3.00E+4nMAssay Description:PI3K p110δ/p85α (human) was incubated in an assay buffer comprising 10 μM phosphati-dylinositol 4,5-bisphosphate and MgATP (concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
Go to US Patent

LigandPNGBDBM418464(7-Methoxy-1-(3-methoxy- pyridin-4-yl)-3-methyl-8- ...)
Affinity DataIC50: 3.00E+4nMAssay Description:PI3K p110α/p85α (human) was incubated in an assay buffer comprising 10 μM phosphati-dylinositol 4,5-bisphosphate and MgATP (concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
Go to US Patent

TargetSerine-protein kinase ATM(Human)
Merck Patent

US Patent
LigandPNGBDBM418464(7-Methoxy-1-(3-methoxy- pyridin-4-yl)-3-methyl-8- ...)
Affinity DataIC50: 10nMAssay Description:The IC50 value was determined with the aid of a biochemical ATM kinase assay. The assay consists of two steps: the enzymatic reaction and the detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
Go to US Patent