BDBM417065 4-((6-chloro-3,4-dihydroquinolin-1(2H)-yl)methyl)-3-fluoro-N-hydroxybenzamide::US10456394, Example 3

SMILES ONC(=O)c1ccc(CN2CCCc3cc(Cl)ccc23)c(F)c1

InChI Key InChIKey=YWGJBRYPUNDFFF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 417065   

TargetHistone deacetylase 1(Human)
University of Illinois

US Patent
LigandPNGBDBM417065(4-((6-chloro-3,4-dihydroquinolin-1(2H)-yl)methyl)-...)
Affinity DataIC50: 2.12E+4nMAssay Description:The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
Go to US Patent

TargetHistone deacetylase 6(Human)
University of Illinois

US Patent
LigandPNGBDBM417065(4-((6-chloro-3,4-dihydroquinolin-1(2H)-yl)methyl)-...)
Affinity DataIC50: 12.4nMAssay Description:The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
Go to US Patent

TargetHistone deacetylase 1(Human)
University of Illinois

US Patent
LigandPNGBDBM417065(4-((6-chloro-3,4-dihydroquinolin-1(2H)-yl)methyl)-...)
Affinity DataIC50: 12nMAssay Description:Inhibition of full length recombinant human HDAC1 expressed in baculovirus infected Sf9 insect cells using RHKKAc fluorogenic peptide as substrate pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Illinois

US Patent
LigandPNGBDBM417065(4-((6-chloro-3,4-dihydroquinolin-1(2H)-yl)methyl)-...)
Affinity DataIC50: 2.12E+4nMAssay Description:Inhibition of full length recombinant human HDAC6 expressed in baculovirus infected Sf9 insect cells using RHKKAc fluorogenic peptide as substrate pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed