BDBM417063 4-((3,4-dihydroquinolin-1(2H)-yl)methyl)-N-hydroxybenzamide ::US10456394, Example 1

SMILES ONC(=O)c1ccc(CN2CCCc3ccccc23)cc1

InChI Key InChIKey=NQVDRCWYKLNRPA-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 417063   

TargetHistone deacetylase 1(Human)
University of Illinois

US Patent
LigandPNGBDBM417063(4-((3,4-dihydroquinolin-1(2H)-yl)methyl)-N-hydroxy...)
Affinity DataIC50: 1.11E+4nMAssay Description:The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
Go to US Patent

TargetHistone deacetylase 6(Human)
University of Illinois

US Patent
LigandPNGBDBM417063(4-((3,4-dihydroquinolin-1(2H)-yl)methyl)-N-hydroxy...)
Affinity DataIC50: 14.6nMAssay Description:The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
Go to US Patent

TargetHistone deacetylase 1(Human)
University of Illinois

US Patent
LigandPNGBDBM417063(4-((3,4-dihydroquinolin-1(2H)-yl)methyl)-N-hydroxy...)
Affinity DataIC50: 15nMAssay Description:Inhibition of full length recombinant C-terminal FLAG-His-tagged human HDAC1 expressed in baculovirus infected Sf21 insect cells using RHK-K(Ac)-AMC ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Illinois

US Patent
LigandPNGBDBM417063(4-((3,4-dihydroquinolin-1(2H)-yl)methyl)-N-hydroxy...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of full length recombinant N-terminal GST-tagged human HDAC6 expressed in baculovirus infected Sf9 insect cells using RHK-K(Ac)-AMC peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
University of Illinois

US Patent
LigandPNGBDBM417063(4-((3,4-dihydroquinolin-1(2H)-yl)methyl)-N-hydroxy...)
Affinity DataIC50: 5.23E+3nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM417063(4-((3,4-dihydroquinolin-1(2H)-yl)methyl)-N-hydroxy...)
Affinity DataIC50: 3.28E+4nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM417063(4-((3,4-dihydroquinolin-1(2H)-yl)methyl)-N-hydroxy...)
Affinity DataIC50: 2.95E+4nMAssay Description:Inhibition of HDAC3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
University of Illinois

US Patent
LigandPNGBDBM417063(4-((3,4-dihydroquinolin-1(2H)-yl)methyl)-N-hydroxy...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed