BDBM416775 1-(3-(aminomethyl)phenyl)-N-(3-((cyclopropylmethoxy)(phenyl)methyl)phenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::US10329260, Compound 18k::US10633345, Compound 74a::US10689346, Compound 165e::US11203574, Compound 165e::US11230530, Compound 165e::US11685721, Compound 18k::US11708332, Compound 18k

SMILES NCc1cccc(c1)-n1nc(cc1C(=O)Nc1cccc(c1)C(OCC1CC1)c1ccccc1)C(F)(F)F

InChI Key InChIKey=PEZVPVUPSJXZCH-UHFFFAOYSA-N

Data  20 KI  5 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 416775   

TargetPlasma kallikrein(Human)
Biocryst Pharmaceuticals

Curated by ChEMBL

LigandBDBM416775(US10329260, Compound 18k | 1-(3-(aminomethyl)pheny...)Copy SMILESCopy InChI

Affinity DataIC50: 300nMAssay Description:Inhibition of endogenous human plasma kallikrein using Z-Phe-Arg-AMC.HCl as substrate measured after 5 mins by microplate reader analysisMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/26/2023
Entry Details
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TargetPlasma kallikrein(Human)
Biocryst Pharmaceuticals

Curated by ChEMBL

LigandBDBM416775(US10329260, Compound 18k | 1-(3-(aminomethyl)pheny...)Copy SMILESCopy InChI

Affinity DataIC50: 38nMAssay Description:Inhibition of purified human plasma kallikrein using H-D-Pro-Phe-Arg-pNA.2HCl as substrate measured after 3 mins by microplate reader analysisMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/26/2023
Entry Details
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TargetPlasma kallikrein(Human)
Biocryst Pharmaceuticals

Curated by ChEMBL

LigandBDBM416775(US10329260, Compound 18k | 1-(3-(aminomethyl)pheny...)Copy SMILESCopy InChI

Affinity DataIC50: 100nMAssay Description:Inhibition of human plasma kallikrein using H-D-Pro-Phe-Arg-p-nitroaniline as substrate assessed as inhibition constantMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
4/19/2024
Entry Details
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TargetPlasma kallikrein(Human)
Biocryst Pharmaceuticals

Curated by ChEMBL

LigandBDBM416775(US10329260, Compound 18k | 1-(3-(aminomethyl)pheny...)Copy SMILESCopy InChI

Affinity DataIC50: 300nMAssay Description:Inhibition of endogenous human plasma kallikrein using Z-Phe-Arg-AMC.HCl as substrate measured after 5 mins by microplate reader analysisMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/24/2022
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetPlasma kallikrein(Human)
Biocryst Pharmaceuticals

Curated by ChEMBL

LigandBDBM416775(US10329260, Compound 18k | 1-(3-(aminomethyl)pheny...)Copy SMILESCopy InChI

Affinity DataIC50: 38nMAssay Description:Inhibition of purified human plasma kallikrein using H-D-Pro-Phe-Arg-pNA.2HCl as substrate measured after 3 mins by microplate reader analysisMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/24/2022
Entry Details Article
Copy Entry DOIPubMed
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TargetPlasma kallikrein(Human)
Biocryst Pharmaceuticals

Curated by ChEMBL

LigandBDBM416775(US10329260, Compound 18k | 1-(3-(aminomethyl)pheny...)Copy SMILESCopy InChI

Affinity DataKi:  0.100nMAssay Description:Inhibition of human plasma kallikrein using H-D-Pro-Phe-Arg-p-nitroaniline as substrate assessed as inhibition constantMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
4/19/2024
Entry Details
Copy Entry DOIPubMed
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TargetPlasma kallikrein(Human)
Biocryst Pharmaceuticals

Curated by ChEMBL

LigandBDBM416775(US10329260, Compound 18k | 1-(3-(aminomethyl)pheny...)Copy SMILESCopy InChI

Affinity DataKi:  25.1nMAssay Description:Plasma kallikrein activity assay. The effect of compounds of the invention on human plasma kallikrein activity was determined using the chromogenic s...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
5/29/2022
Entry Details
Copy Entry DOIGo to US Patent

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TargetPlasma kallikrein(Human)
Biocryst Pharmaceuticals

Curated by ChEMBL

LigandBDBM416775(US10329260, Compound 18k | 1-(3-(aminomethyl)pheny...)Copy SMILESCopy InChI

Affinity DataKi:  25.1nMAssay Description:Plasma kallikrein activity assay. The effect of compounds of the invention on human plasma kallikrein activity was determined using the chromogenic s...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
7/31/2023
Entry Details
Copy Entry DOIGo to US Patent

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TargetPlasma kallikrein(Human)
Biocryst Pharmaceuticals

Curated by ChEMBL

LigandBDBM416775(US10329260, Compound 18k | 1-(3-(aminomethyl)pheny...)Copy SMILESCopy InChI

Affinity DataKi:  25.1nMAssay Description:Plasma kallikrein activity assay. The effect of compounds of the invention on human plasma kallikrein activity was determined using the chromogenic s...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
7/31/2023
Entry Details
Copy Entry DOIGo to US Patent

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TargetPlasma kallikrein(Human)
Biocryst Pharmaceuticals

Curated by ChEMBL

LigandBDBM416775(US10329260, Compound 18k | 1-(3-(aminomethyl)pheny...)Copy SMILESCopy InChI

Affinity DataKi:  25.1nMAssay Description:The effect of compounds of the invention on human plasma kallikrein activity was determined using the chromogenic substrates (DiaPharma Group, Inc., ...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/27/2023
Entry Details
Copy Entry DOIGo to US Patent

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TargetPlasma kallikrein(Human)
Biocryst Pharmaceuticals

Curated by ChEMBL

LigandBDBM416775(US10329260, Compound 18k | 1-(3-(aminomethyl)pheny...)Copy SMILESCopy InChI

Affinity DataKi:  25.1nMAssay Description:The effect of compounds of the invention on human plasma kallikrein activity was determined using the chromogenic substrates (DiaPharma Group, Inc., ...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/27/2023
Entry Details
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TargetPlasma kallikrein(Human)
Biocryst Pharmaceuticals

Curated by ChEMBL

LigandBDBM416775(US10329260, Compound 18k | 1-(3-(aminomethyl)pheny...)Copy SMILESCopy InChI

Affinity DataKi:  25.1nMAssay Description:The effect of compounds of the invention on human plasma kallikrein activity was determined using the chromogenic substrates (DiaPharma Group, Inc., ...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
4/17/2022
Entry Details
Copy Entry DOIGo to US Patent

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TargetPlasma kallikrein(Human)
Biocryst Pharmaceuticals

Curated by ChEMBL

LigandBDBM416775(US10329260, Compound 18k | 1-(3-(aminomethyl)pheny...)Copy SMILESCopy InChI

Affinity DataKi:  25.1nMAssay Description:The effect of compounds of the invention on human plasma kallikrein activity was determined using the chromogenic substrates (DiaPharma Group, Inc., ...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
4/17/2022
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetPlasma kallikrein(Human)
Biocryst Pharmaceuticals

Curated by ChEMBL

LigandBDBM416775(US10329260, Compound 18k | 1-(3-(aminomethyl)pheny...)Copy SMILESCopy InChI

Affinity DataKi:  25.1nMAssay Description:The effect of compounds of the invention on human plasma kallikrein activity was determined using the chromogenic substrates (DiaPharma Group, Inc., ...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/24/2020
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetPlasma kallikrein(Human)
Biocryst Pharmaceuticals

Curated by ChEMBL

LigandBDBM416775(US10329260, Compound 18k | 1-(3-(aminomethyl)pheny...)Copy SMILESCopy InChI

Affinity DataKi:  25.1nMAssay Description:Plasma kallikrein activity assay. The effect of compounds of the invention on human plasma kallikrein activity was determined using the chromogenic s...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
5/29/2022
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetPlasma kallikrein(Human)
Biocryst Pharmaceuticals

Curated by ChEMBL

LigandBDBM416775(US10329260, Compound 18k | 1-(3-(aminomethyl)pheny...)Copy SMILESCopy InChI

Affinity DataKi:  25.1nMAssay Description:The effect of compounds of the invention on human plasma kallikrein activity was determined using the chromogenic substrates (DiaPharma Group, Inc., ...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
4/17/2022
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetPlasma kallikrein(Human)
Biocryst Pharmaceuticals

Curated by ChEMBL

LigandBDBM416775(US10329260, Compound 18k | 1-(3-(aminomethyl)pheny...)Copy SMILESCopy InChI

Affinity DataKi:  25.1nMAssay Description:Plasma kallikrein activity assay. The effect of compounds of the invention on human plasma kallikrein activity was determined using the chromogenic s...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
5/29/2022
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetPlasma kallikrein(Human)
Biocryst Pharmaceuticals

Curated by ChEMBL

LigandBDBM416775(US10329260, Compound 18k | 1-(3-(aminomethyl)pheny...)Copy SMILESCopy InChI

Affinity DataKi:  25.1nMAssay Description:The effect of compounds of the invention on human plasma kallikrein activity was determined using the chromogenic substrates (DiaPharma Group, Inc., ...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
4/29/2022
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetPlasma kallikrein(Human)
Biocryst Pharmaceuticals

Curated by ChEMBL

LigandBDBM416775(US10329260, Compound 18k | 1-(3-(aminomethyl)pheny...)Copy SMILESCopy InChI

Affinity DataKi:  25.1nMAssay Description:The effect of compounds of the invention on human plasma kallikrein activity was determined using the chromogenic substrates (DiaPharma Group, Inc., ...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
4/29/2022
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetPlasma kallikrein(Human)
Biocryst Pharmaceuticals

Curated by ChEMBL

LigandBDBM416775(US10329260, Compound 18k | 1-(3-(aminomethyl)pheny...)Copy SMILESCopy InChI

Affinity DataKi:  25.1nMAssay Description:The effect of compounds of the invention on human plasma kallikrein activity was determined using the chromogenic substrates. In these experiments, 2...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/22/2021
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetPlasma kallikrein(Human)
Biocryst Pharmaceuticals

Curated by ChEMBL

LigandBDBM416775(US10329260, Compound 18k | 1-(3-(aminomethyl)pheny...)Copy SMILESCopy InChI

Affinity DataKi:  25.1nMAssay Description:The effect of compounds of the invention on human plasma kallikrein activity was determined using the chromogenic substrates. In these experiments, 2...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/22/2021
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetPlasma kallikrein(Human)
Biocryst Pharmaceuticals

Curated by ChEMBL

LigandBDBM416775(US10329260, Compound 18k | 1-(3-(aminomethyl)pheny...)Copy SMILESCopy InChI

Affinity DataKi:  25.1nMAssay Description:The effect of compounds of the invention on human plasma kallikrein activity was determined using the chromogenic substrates. In these experiments, 2...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/22/2021
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetPlasma kallikrein(Human)
Biocryst Pharmaceuticals

Curated by ChEMBL

LigandBDBM416775(US10329260, Compound 18k | 1-(3-(aminomethyl)pheny...)Copy SMILESCopy InChI

Affinity DataKi:  25.1nMAssay Description:The effect of compounds of the invention on human plasma kallikrein activity was determined using the chromogenic substrates (DiaPharma Group, Inc., ...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
1/10/2021
Entry Details
Copy Entry DOIGo to US Patent

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TargetPlasma kallikrein(Human)
Biocryst Pharmaceuticals

Curated by ChEMBL

LigandBDBM416775(US10329260, Compound 18k | 1-(3-(aminomethyl)pheny...)Copy SMILESCopy InChI

Affinity DataKi:  25.1nMAssay Description:The effect of compounds of the invention on human plasma kallikrein activity was determined using the chromogenic substrates (DiaPharma Group, Inc., ...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
1/10/2021
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetPlasma kallikrein(Human)
Biocryst Pharmaceuticals

Curated by ChEMBL

LigandBDBM416775(US10329260, Compound 18k | 1-(3-(aminomethyl)pheny...)Copy SMILESCopy InChI

Affinity DataKi:  25.1nMAssay Description:The effect of compounds of the invention on human plasma kallikrein activity was determined using the chromogenic substrates (DiaPharma Group, Inc., ...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
1/10/2021
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL