BDBM416280 6-[(4- methoxycyclohexyl)carbonyl]-8- (tetrahydro-2H-pyran-4- ylmethyl)-6,11-dihydro-5H- pyrido[2,3- b][1,5]benzodiazepine::US10442819, Example 424::US10442819, Example 429

SMILES COC1CCC(CC1)C(=O)N1Cc2cccnc2Nc2ccc(CC3CCOCC3)cc12

InChI Key InChIKey=LWZNFSXOBICSEQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 416280   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM416280(US10442819, Example 424 | US10442819, Example 429 ...)
Affinity DataIC50: 44nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series. 125 nL of each dilution or DMSO alone is disp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
Go to US Patent

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM416280(US10442819, Example 424 | US10442819, Example 429 ...)
Affinity DataIC50: 14nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series. 125 nL of each dilution or DMSO alone is disp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
Go to US Patent