BDBM414100 (R)-6-(6-chloro-1H- pyrrolo[2,3-b]pyridin-4- yl)-7-methyl-4-((S)-3- (methylsulfonyl)- pyrrolidin-1-yl)-5,6,7,8- tetrahydropyrido[4,3-d]- pyrimidine::US10421765, Example 86::US10745420, Example 86

SMILES C[C@@H]1Cc2ncnc(N3CC[C@@H](C3)S(C)(=O)=O)c2CN1c1cc(Cl)nc2[nH]ccc12

InChI Key InChIKey=OZUOSKSLWGOPHF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 414100   

TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Human)
University Of Texas

US Patent
LigandPNGBDBM414100(US10421765, Example 86 | (R)-6-(6-chloro-1H- pyrro...)
Affinity DataIC50: 329nMAssay Description:Human full-length FLAG-TEV-ATR and His6-ATRIP were co-expressed in HEK293 cells. The cell pellet (20 g) was harvested and lysed in 100 mL of lysis bu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2020
Entry Details
Go to US Patent

TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Human)
University Of Texas

US Patent
LigandPNGBDBM414100(US10421765, Example 86 | (R)-6-(6-chloro-1H- pyrro...)
Affinity DataIC50: 329nMAssay Description:Human full-length FLAG-TEV-ATR and His6-ATRIP were co-expressed in HEK293 cells. The cell pellet (20 g) was harvested and lysed in 100 mL of lysis bu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2021
Entry Details
Go to US Patent