BDBM414079 (7R)-6-(6-chloro-1H- pyrrolo[2,3-b]pyridin-4- yl)-7-methyl-4-(3- (methylsulfonyl)- piperidin-1-yl)-5,6,7,8- tetrahydropyrido[4,3-d]- pyrimidine::US10421765, Example 65::US10745420, Example 65

SMILES C[C@@H]1Cc2ncnc(N3CCCC(C3)S(C)(=O)=O)c2CN1c1cc(Cl)nc2[nH]ccc12

InChI Key InChIKey=QIOHFPGOWNSPLM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 414079   

TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Human)
University Of Texas

US Patent
LigandPNGBDBM414079(US10421765, Example 65 | (7R)-6-(6-chloro-1H- pyrr...)
Affinity DataIC50: 159nMAssay Description:Human full-length FLAG-TEV-ATR and His6-ATRIP were co-expressed in HEK293 cells. The cell pellet (20 g) was harvested and lysed in 100 mL of lysis bu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2020
Entry Details
Go to US Patent

TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Human)
University Of Texas

US Patent
LigandPNGBDBM414079(US10421765, Example 65 | (7R)-6-(6-chloro-1H- pyrr...)
Affinity DataIC50: 159nMAssay Description:Human full-length FLAG-TEV-ATR and His6-ATRIP were co-expressed in HEK293 cells. The cell pellet (20 g) was harvested and lysed in 100 mL of lysis bu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2021
Entry Details
Go to US Patent