BDBM413575 (2S)—N-[(1S)-1-[[(1S)-3-[(3,5-difluorobenzoyl)amino]-1-(hydroxycarbamoyl)propyl]carbamoyl]-2-methyl-butyl]-N-methyl-1-(2-propylpentanoyl)pyrrolidine-2-carboxamide::US10414797, Example 8

SMILES CCCC(CCC)C(=O)N1CCC[C@H]1C(=O)N(C)[C@@H](C(C)CC)C(=O)N[C@@H](CCNC(=O)c1cc(F)cc(F)c1)C(=O)NO

InChI Key InChIKey=NOOQCZHLXNSKQR-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 413575   

TargetMetalloproteinase inhibitor 2(Long-tailed dwarf hamster)
Iproteos

US Patent
LigandPNGBDBM413575((2S)—N-[(1S)-1-[[(1S)-3-[(3,5-difluorobenzoyl...)
Affinity DataIC50: 974nMAssay Description:MMP-2: Recombinant MMP-2 expressed in Chinese hamster ovary (CHO) cells was obtained from Merck-Millipore (catalog number PF023-5UG). DQ gelatin from...More data for this Ligand-Target Pair
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US Patent

TargetMatrix metalloproteinase-9(Human)
Iproteos

US Patent
LigandPNGBDBM413575((2S)—N-[(1S)-1-[[(1S)-3-[(3,5-difluorobenzoyl...)
Affinity DataIC50: 263nMAssay Description:MMP-9: Recombinant MMP-9 expressed was obtained from Merck-Millipore (catalog number PF140-5UG, used in examples 1 to 9 and comparative examples) and...More data for this Ligand-Target Pair
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US Patent

TargetInterstitial collagenase(Human)
Iproteos

US Patent
LigandPNGBDBM413575((2S)—N-[(1S)-1-[[(1S)-3-[(3,5-difluorobenzoyl...)
Affinity DataIC50: 3.65E+6nMAssay Description:MMP-1:MMP-1 peptide substrate was provided as a stock solution in DMSO (6 mM). For the assay, the substrate was diluted 1× reaction buffer to a conce...More data for this Ligand-Target Pair
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US Patent

TargetStromelysin-1(Human)
Iproteos

US Patent
LigandPNGBDBM413575((2S)—N-[(1S)-1-[[(1S)-3-[(3,5-difluorobenzoyl...)
Affinity DataIC50: 3.81E+6nMAssay Description:MMP-3: Preparation of the MMP-3 for the activity assay: MMP-3 was provided as a stock solution (0.1 mg/mL). The enzyme was diluted in water to a fina...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

TargetMatrilysin(Human)
Iproteos

US Patent
LigandPNGBDBM413575((2S)—N-[(1S)-1-[[(1S)-3-[(3,5-difluorobenzoyl...)
Affinity DataIC50: 4.10E+6nMAssay Description:MMP-7: Recombinant MMP-7 expressed in E. Coli was obtained from Merck-Millipore (catalog number 44270). Mca-PLGL-Dpa-AR-NH2 (fluorogenic peptide subs...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent