BDBM413460 9-cyclohexyl-7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino)-7,9-dihydro-8H-purin-8-one::US10407446, Example 13::US11136340, Example 13

SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n(C3CCCCC3)c2n1

InChI Key InChIKey=PCTWMWBDQSWVBE-UHFFFAOYSA-N

Data  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 413460   

TargetDual specificity protein kinase TTK(Human)
Astrazeneca

US Patent
LigandPNGBDBM413460(US10407446, Example 13 | 9-cyclohexyl-7-methyl-2-(...)
Affinity DataIC50: 501nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTE assays run by ThermoFisher Scientific ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Astrazeneca

US Patent
LigandPNGBDBM413460(US10407446, Example 13 | 9-cyclohexyl-7-methyl-2-(...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTE assays run by ThermoFisher Scientific ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca

US Patent
LigandPNGBDBM413460(US10407446, Example 13 | 9-cyclohexyl-7-methyl-2-(...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTE assays run by ThermoFisher Scientific ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Astrazeneca

US Patent
LigandPNGBDBM413460(US10407446, Example 13 | 9-cyclohexyl-7-methyl-2-(...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTE assays run by ThermoFisher Scientific ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

TargetAurora kinase A(Human)
Astrazeneca

US Patent
LigandPNGBDBM413460(US10407446, Example 13 | 9-cyclohexyl-7-methyl-2-(...)
Affinity DataIC50: 3.98E+3nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTE assays run by ThermoFisher Scientific ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

TargetAurora kinase B(Human)
Astrazeneca

US Patent
LigandPNGBDBM413460(US10407446, Example 13 | 9-cyclohexyl-7-methyl-2-(...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTE assays run by ThermoFisher Scientific ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM413460(US10407446, Example 13 | 9-cyclohexyl-7-methyl-2-(...)
Affinity DataIC50: 0.158nMAssay Description:Inhibition of human HeLa cell-derived full length DNA-PK catalytic subunit using fluorescein-EPPLSQEAFADLWKK as substrate preincubated for 30 mins fo...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails Article
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM413460(US10407446, Example 13 | 9-cyclohexyl-7-methyl-2-(...)
Affinity DataIC50: 25nMAssay Description:Inhibition of DNA-PK in human A549 cells assessed as reduction in irradiation-induced autophosphorylation at S2056 residue preincubated for 1 hr foll...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails Article
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM413460(US10407446, Example 13 | 9-cyclohexyl-7-methyl-2-(...)
Affinity DataIC50: 0.158nMAssay Description:The inhibitory activity of compounds against DNAPK was determined by TR-FRET measuring a fluorescent labelled peptide substrate converting to a phosp...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

TargetDual specificity protein kinase TTK(Human)
Astrazeneca

US Patent
LigandPNGBDBM413460(US10407446, Example 13 | 9-cyclohexyl-7-methyl-2-(...)
Affinity DataIC50: 501nMAssay Description:The inhibitory activity of compounds against TTK was determined in a LanthaScreen Eu Kinase Binding assay run by ThermoFisher Scientific as part of t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Astrazeneca

US Patent
LigandPNGBDBM413460(US10407446, Example 13 | 9-cyclohexyl-7-methyl-2-(...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTE assays run by ThermoFisher Scientific as...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca

US Patent
LigandPNGBDBM413460(US10407446, Example 13 | 9-cyclohexyl-7-methyl-2-(...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTE assays run by ThermoFisher Scientific as...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Astrazeneca

US Patent
LigandPNGBDBM413460(US10407446, Example 13 | 9-cyclohexyl-7-methyl-2-(...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTE assays run by ThermoFisher Scientific as...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

TargetAurora kinase A(Human)
Astrazeneca

US Patent
LigandPNGBDBM413460(US10407446, Example 13 | 9-cyclohexyl-7-methyl-2-(...)
Affinity DataIC50: 3.98E+3nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTE assays run by ThermoFisher Scientific as...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

TargetAurora kinase B(Human)
Astrazeneca

US Patent
LigandPNGBDBM413460(US10407446, Example 13 | 9-cyclohexyl-7-methyl-2-(...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTE assays run by ThermoFisher Scientific as...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent