BDBM413457 9-((1s,4s)-4-hydroxy-4-methylcyclohexyl)-7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino)-7,9-dihydro-8H-purin-8-one::US10407446, Example 10::US11136340, Example 10

SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n([C@H]3CC[C@@](C)(O)CC3)c2n1

InChI Key InChIKey=FAPBUMXELNHUHE-UHFFFAOYSA-N

Data  16 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 413457   

TargetDual specificity protein kinase TTK(Human)
Astrazeneca

US Patent
LigandPNGBDBM413457(US10407446, Example 10 | 9-((1s,4s)-4-hydroxy-4-me...)
Affinity DataIC50: 501nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTE assays run by ThermoFisher Scientific ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
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TargetTyrosine-protein kinase JAK1(Human)
Astrazeneca

US Patent
LigandPNGBDBM413457(US10407446, Example 10 | 9-((1s,4s)-4-hydroxy-4-me...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTE assays run by ThermoFisher Scientific ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca

US Patent
LigandPNGBDBM413457(US10407446, Example 10 | 9-((1s,4s)-4-hydroxy-4-me...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTE assays run by ThermoFisher Scientific ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Astrazeneca

US Patent
LigandPNGBDBM413457(US10407446, Example 10 | 9-((1s,4s)-4-hydroxy-4-me...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTE assays run by ThermoFisher Scientific ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
Go to US Patent

TargetAurora kinase A(Human)
Astrazeneca

US Patent
LigandPNGBDBM413457(US10407446, Example 10 | 9-((1s,4s)-4-hydroxy-4-me...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTE assays run by ThermoFisher Scientific ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
Go to US Patent

TargetAurora kinase B(Human)
Astrazeneca

US Patent
LigandPNGBDBM413457(US10407446, Example 10 | 9-((1s,4s)-4-hydroxy-4-me...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTE assays run by ThermoFisher Scientific ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
Go to US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM413457(US10407446, Example 10 | 9-((1s,4s)-4-hydroxy-4-me...)
Affinity DataIC50: 63nMAssay Description:Inhibition of DNA-PK in human A549 cells assessed as reduction in irradiation-induced autophosphorylation at S2056 residue preincubated for 1 hr foll...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM413457(US10407446, Example 10 | 9-((1s,4s)-4-hydroxy-4-me...)
Affinity DataIC50: 0.398nMAssay Description:Inhibition of human HeLa cell-derived full length DNA-PK catalytic subunit using fluorescein-EPPLSQEAFADLWKK as substrate preincubated for 30 mins fo...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM413457(US10407446, Example 10 | 9-((1s,4s)-4-hydroxy-4-me...)
Affinity DataIC50: 1.98E+5nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -90 mV holding potential by electrophysiological assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM413457(US10407446, Example 10 | 9-((1s,4s)-4-hydroxy-4-me...)
Affinity DataIC50: 0.398nMAssay Description:The inhibitory activity of compounds against DNAPK was determined by TR-FRET measuring a fluorescent labelled peptide substrate converting to a phosp...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetDual specificity protein kinase TTK(Human)
Astrazeneca

US Patent
LigandPNGBDBM413457(US10407446, Example 10 | 9-((1s,4s)-4-hydroxy-4-me...)
Affinity DataIC50: 501nMAssay Description:The inhibitory activity of compounds against TTK was determined in a LanthaScreen Eu Kinase Binding assay run by ThermoFisher Scientific as part of t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Astrazeneca

US Patent
LigandPNGBDBM413457(US10407446, Example 10 | 9-((1s,4s)-4-hydroxy-4-me...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTE assays run by ThermoFisher Scientific as...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca

US Patent
LigandPNGBDBM413457(US10407446, Example 10 | 9-((1s,4s)-4-hydroxy-4-me...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTE assays run by ThermoFisher Scientific as...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Astrazeneca

US Patent
LigandPNGBDBM413457(US10407446, Example 10 | 9-((1s,4s)-4-hydroxy-4-me...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTE assays run by ThermoFisher Scientific as...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetAurora kinase A(Human)
Astrazeneca

US Patent
LigandPNGBDBM413457(US10407446, Example 10 | 9-((1s,4s)-4-hydroxy-4-me...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTE assays run by ThermoFisher Scientific as...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetAurora kinase B(Human)
Astrazeneca

US Patent
LigandPNGBDBM413457(US10407446, Example 10 | 9-((1s,4s)-4-hydroxy-4-me...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTE assays run by ThermoFisher Scientific as...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent