BDBM413456 9-((1r,4r)-4-hydroxy-4-methylcyclohexyl)-7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino)-7,9-dihydro-8H-purin-8-one::US10407446, Example 9::US11136340, Example 9

SMILES Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n([C@H]3CC[C@](C)(O)CC3)c2n1

InChI Key InChIKey=FAPBUMXELNHUHE-UHFFFAOYSA-N

Data  15 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 413456   

TargetDual specificity protein kinase TTK(Human)
Astrazeneca

US Patent

LigandBDBM413456(US10407446, Example 9 | 9-((1r,4r)-4-hydroxy-4-met...)Copy SMILESCopy InChI

Affinity DataIC50: 3.98E+3nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTE assays run by ThermoFisher Scientific ...More data for this Ligand-Target Pair

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TargetTyrosine-protein kinase JAK1(Human)
Astrazeneca

US Patent

LigandBDBM413456(US10407446, Example 9 | 9-((1r,4r)-4-hydroxy-4-met...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTE assays run by ThermoFisher Scientific ...More data for this Ligand-Target Pair

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UniProtKB/SwissProt
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TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca

US Patent

LigandBDBM413456(US10407446, Example 9 | 9-((1r,4r)-4-hydroxy-4-met...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTE assays run by ThermoFisher Scientific ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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TargetTyrosine-protein kinase JAK3(Human)
Astrazeneca

US Patent

LigandBDBM413456(US10407446, Example 9 | 9-((1r,4r)-4-hydroxy-4-met...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTE assays run by ThermoFisher Scientific ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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TargetAurora kinase A(Human)
Astrazeneca

US Patent

LigandBDBM413456(US10407446, Example 9 | 9-((1r,4r)-4-hydroxy-4-met...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTE assays run by ThermoFisher Scientific ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

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TargetAurora kinase B(Human)
Astrazeneca

US Patent

LigandBDBM413456(US10407446, Example 9 | 9-((1r,4r)-4-hydroxy-4-met...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTE assays run by ThermoFisher Scientific ...More data for this Ligand-Target Pair

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UniProtKB/SwissProt
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TargetDNA-dependent protein kinase catalytic subunit(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM413456(US10407446, Example 9 | 9-((1r,4r)-4-hydroxy-4-met...)Copy SMILESCopy InChI

Affinity DataIC50: 0.316nMAssay Description:Inhibition of human HeLa cell-derived full length DNA-PK catalytic subunit using fluorescein-EPPLSQEAFADLWKK as substrate preincubated for 30 mins fo...More data for this Ligand-Target Pair

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TargetDNA-dependent protein kinase catalytic subunit(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM413456(US10407446, Example 9 | 9-((1r,4r)-4-hydroxy-4-met...)Copy SMILESCopy InChI

Affinity DataIC50: 126nMAssay Description:Inhibition of DNA-PK in human A549 cells assessed as reduction in irradiation-induced autophosphorylation at S2056 residue preincubated for 1 hr foll...More data for this Ligand-Target Pair

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TargetDNA-dependent protein kinase catalytic subunit(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM413456(US10407446, Example 9 | 9-((1r,4r)-4-hydroxy-4-met...)Copy SMILESCopy InChI

Affinity DataIC50: 0.316nMAssay Description:The inhibitory activity of compounds against DNAPK was determined by TR-FRET measuring a fluorescent labelled peptide substrate converting to a phosp...More data for this Ligand-Target Pair

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TargetDual specificity protein kinase TTK(Human)
Astrazeneca

US Patent

LigandBDBM413456(US10407446, Example 9 | 9-((1r,4r)-4-hydroxy-4-met...)Copy SMILESCopy InChI

Affinity DataIC50: 3.98E+3nMAssay Description:The inhibitory activity of compounds against TTK was determined in a LanthaScreen Eu Kinase Binding assay run by ThermoFisher Scientific as part of t...More data for this Ligand-Target Pair

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UniProtKB/SwissProt
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TargetTyrosine-protein kinase JAK1(Human)
Astrazeneca

US Patent

LigandBDBM413456(US10407446, Example 9 | 9-((1r,4r)-4-hydroxy-4-met...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTE assays run by ThermoFisher Scientific as...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca

US Patent

LigandBDBM413456(US10407446, Example 9 | 9-((1r,4r)-4-hydroxy-4-met...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTE assays run by ThermoFisher Scientific as...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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TargetTyrosine-protein kinase JAK3(Human)
Astrazeneca

US Patent

LigandBDBM413456(US10407446, Example 9 | 9-((1r,4r)-4-hydroxy-4-met...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTE assays run by ThermoFisher Scientific as...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

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TargetAurora kinase A(Human)
Astrazeneca

US Patent

LigandBDBM413456(US10407446, Example 9 | 9-((1r,4r)-4-hydroxy-4-met...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTE assays run by ThermoFisher Scientific as...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

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TargetAurora kinase B(Human)
Astrazeneca

US Patent

LigandBDBM413456(US10407446, Example 9 | 9-((1r,4r)-4-hydroxy-4-met...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTE assays run by ThermoFisher Scientific as...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

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