BDBM412772 3-methyl-N-{2-[6-(trifluoromethyl)pyridin-2-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}pyridin-4-amine::US10399987, Example 37

SMILES Cc1cnccc1Nc1nc(nc2[nH]ccc12)-c1cccc(n1)C(F)(F)F

InChI Key InChIKey=OLMTUPIGVFMHDY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 412772   

TargetTGF-beta receptor type-1 [4-503,T204D](Human)
Bristol-Myer Squibb

US Patent
LigandPNGBDBM412772(US10399987, Example 37 | 3-methyl-N-{2-[6-(trifluo...)
Affinity DataIC50: 0.870nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

TargetTGF-beta receptor type-2(Human)
Bristol-Myer Squibb

US Patent
LigandPNGBDBM412772(US10399987, Example 37 | 3-methyl-N-{2-[6-(trifluo...)
Affinity DataIC50: 1.50E+4nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent