BDBM412742 2-(6-(difluoromethyl)pyridin-2-yl)-N-(3-fluoropyridin-4-yl)-5-((4-methylpiperazin-1-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine::US10399987, Example 7

SMILES CN1CCN(Cc2c[nH]c3nc(nc(Nc4ccncc4F)c23)-c2cccc(n2)C(F)F)CC1

InChI Key InChIKey=JKSJAYCIWZKWQY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 412742   

TargetTGF-beta receptor type-1 [4-503,T204D](Human)
Bristol-Myer Squibb

US Patent
LigandPNGBDBM412742(US10399987, Example 7 | 2-(6-(difluoromethyl)pyrid...)
Affinity DataIC50: 3.70nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

TargetTGF-beta receptor type-2(Human)
Bristol-Myer Squibb

US Patent
LigandPNGBDBM412742(US10399987, Example 7 | 2-(6-(difluoromethyl)pyrid...)
Affinity DataIC50: 1.50E+4nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent