BDBM409781 2-oxo-4- (p-tolyl)-1H- quinoline-3- carbonitrile::US10370336, Example 1-9

SMILES Cc1ccc(cc1)-c1c(C#N)c(=O)[nH]c2ccccc12

InChI Key InChIKey=GNDFTZVYDQRFCD-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 409781   

LigandPNGBDBM409781(2-oxo-4- (p-tolyl)-1H- quinoline-3- carbonitrile |...)
Affinity DataIC50: 450nMAssay Description:Inhibition of PDE1C (147 to 531 residues) (unknown origin) using 3H-cGMP as substrate incubated for 15 mins by liquid scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM409781(2-oxo-4- (p-tolyl)-1H- quinoline-3- carbonitrile |...)
Affinity DataIC50: 8.90nMAssay Description:Inhibition of PDE9A (181 to 506 residues) (unknown origin) using 3H-cGMP as substrate incubated for 15 mins by liquid scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
LigandPNGBDBM409781(2-oxo-4- (p-tolyl)-1H- quinoline-3- carbonitrile |...)
Affinity DataKi:  8.90nMAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
Go to US Patent