BDBM408034 US10336774, Example 3

SMILES N[C@@H]1CCCC11CCN(CC1)c1cnc(Sc2cccc(Cl)c2Cl)c(N)n1

InChI Key InChIKey=PHTSSQVKMKXPJB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 408034   

LigandPNGBDBM408034(US10336774, Example 3)
Affinity DataIC50: 10nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

LigandPNGBDBM408034(US10336774, Example 3)
Affinity DataIC50: 10nMAssay Description:Allosteric inhibition of [IRSl_pY1172(dPEG8)pY1222] peptide-activated SHP2 (unknown origin) using DiFMUP as substrate preincubated for 30 to 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed