BDBM407111 4-(8-oxabicyclo[3.2.1] octan-3-ylamino)-6-(3- cyanopyrrolo[1,2- b]pyridazin-7-yl)-N-((R)-2- fluoro-3- hydroxy-3-methylbutyl) nicotinamide::US10336762, Compound 50

SMILES CC(C)(O)[C@H](F)CNC(=O)c1cnc(cc1NC1CC2CCC(C1)O2)-c1ccc2cc(cnn12)C#N

InChI Key InChIKey=HFNDSPXQHZRZJX-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 407111   

TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407111(4-(8-oxabicyclo[3.2.1] octan-3-ylamino)-6-(3- cyan...)
Affinity DataEC50:  351nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407111(4-(8-oxabicyclo[3.2.1] octan-3-ylamino)-6-(3- cyan...)
Affinity DataIC50: 3nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent