BDBM407103 (R)-6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-N-(2-fluoro- 3-hydroxy-3- methylbutyl)-4-((tetrahydro- 2H-pyran- 4-yl)amino)nicotinamide::US10336762, Compound 42

SMILES CC(C)(O)[C@H](F)CNC(=O)c1cnc(cc1NC1CCOCC1)-c1ccc2cc(cnn12)C#N

InChI Key InChIKey=XHVNPGUBANKDQY-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 407103   

TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407103((R)-6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-N-(2-...)
Affinity DataEC50:  35nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407103((R)-6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-N-(2-...)
Affinity DataIC50: 1nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent