BDBM407083 6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-4-(isopropyl- amino)-N-((1r,4r)-4- (methylcarbamoyl) cyclohexyl) nicotinamide::US10336762, Compound 22

SMILES CNC(=O)[C@H]1CCC(CC1)NC(=O)c1cnc(cc1NC(C)C)-c1ccc2cc(cnn12)C#N

InChI Key InChIKey=XXFHFGBQBPUDKV-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 407083   

TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407083(6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-4-(isopro...)
Affinity DataEC50:  87nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407083(6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-4-(isopro...)
Affinity DataIC50: 1nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent