BDBM407079 6-(3-cyanopyrrolo[1,2-b] pyridazin-7- yl)-N-(2-(hydroxymethyl) cyclopropyl)- 4-(isopropylamino) nicotinamide::US10336762, Compound 18::US10336762, Compound 45

SMILES CC(C)Nc1cc(ncc1C(=O)NC1CC1CO)-c1ccc2cc(cnn12)C#N

InChI Key InChIKey=TUZNVRHVVWZTFO-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 407079   

TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407079(US10336762, Compound 45 | 6-(3-cyanopyrrolo[1,2-b]...)
Affinity DataEC50:  757nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407079(US10336762, Compound 45 | 6-(3-cyanopyrrolo[1,2-b]...)
Affinity DataIC50: 9nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407079(US10336762, Compound 45 | 6-(3-cyanopyrrolo[1,2-b]...)
Affinity DataEC50:  255nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407079(US10336762, Compound 45 | 6-(3-cyanopyrrolo[1,2-b]...)
Affinity DataIC50: 10nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent