BDBM407078 (R)-6-(3-(1H-tetrazol-5-yl) pyrrolo[1,2-b]pyridazin- 7-yl)-N-(2-fluoro-3- hydroxy-3-methylbutyl)-4- (isopropylamino) nicotinamide::US10336762, Compound 17

SMILES CC(C)Nc1cc(ncc1C(=O)NC[C@@H](F)C(C)(C)O)-c1ccc2cc(cnn12)C1=NNNN1

InChI Key InChIKey=CPIRNQFVFORXMM-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 407078   

TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407078((R)-6-(3-(1H-tetrazol-5-yl) pyrrolo[1,2-b]pyridazi...)
Affinity DataEC50:  5.20E+3nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407078((R)-6-(3-(1H-tetrazol-5-yl) pyrrolo[1,2-b]pyridazi...)
Affinity DataIC50: 24nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent